Searchable abstracts of presentations at key conferences in endocrinology

ea0081p644 | Endocrine-Related Cancer | ECE2022

Sublethal hyperthermia decreases cellular proliferation and transiently disrupts steroidogenesis in adrenal cells

Mullen Nathan , Donlon Padraig , Duffy Katen , Feely Sarah , Warde Kate M , Sorushanova Anna , Prakash Punit , O'Halloran Martin , Dennedy Michael Conall

Introduction: Primary Aldosteronism is the most common cause of secondary hypertension. First-line treatment; adrenalectomy resects adrenal nodules and adjacent normal tissue, limiting suitability to those who present with unilateral disease. Use of thermal ablation represents an emerging approach as a possible minimally invasive therapy for unilateral and bilateral disease, to target and disrupt hypersecreting aldosterone producing adenomas, while preserving adjacent normal a...